中文摘要：

目的观察五味子醇甲对APP/PS1双转基因痴呆模型小鼠脑组织的影响及机制。方法选用APP/PS1双转基因小鼠作为痴呆小鼠模型，五味子醇甲灌胃给药（10 mg·kg-1·d-1），4周后行为学测试，行为学测试后，断头处死，制作脑组织石蜡切片。HE、尼氏染色检测小鼠脑组织的病理形态改变；免疫组织化学方法检测小鼠脑组织突触素（synaptophysin, SYP）、突触核蛋白（α-synuclein, α-syn）的表达。结果五味子醇甲可改善APP/PS1双转基因痴呆模型小鼠脑组织的病理形态改变，提高SYP表达，降低αsyn表达。结论五味子醇甲可通过减轻脑组织神经元变性、脱失，改善突触功能等途径起到防治老年性痴呆（Alzheimer′s disease，AD）的作用。

英文摘要：

Aim To observe the effect of schisandrin - on the APP/PS1 double transgenic dementia mice brain tissue and analyze the mechanism of it. Methods APP/PS1 double transgenic mice were selected as the dementia mice model and were intragastically adminis-tered with schisandrin the mice wre given a to collect their brain sections. Pathological were examined using （10 mg/kg · d）. 4 weeks later, behavior test and then they were tissues for making the paraffin changes of the mice brain tissue HE staining and nissl stainingmethods. The expression levels of synaptophysin （SYP） and α-synuclein （α-syn） in brain tissue were detected using immunohistochemical method. Results Schisandrin promoted the pathological changes of brain tissue in APP/PS1 double transgenic dementia mice, enhanced the expression of SYP, and reduced the expression of α-syn. Conclusions Sehisandrin plays a role in preventing Alzheimer＇ s Disease （AD） by alleviating neurons degeneration and demyelination and improving the function of synapses in brain tissue.