中文摘要：

目的 采用异丙肾上腺素诱导心肌肥厚，建立大鼠模型，并研究该动物模型的基本特性。方法 大鼠背部皮下注射剂 量为 5 mg/kg 的异丙肾上腺素，每日 1 次，连续注射 14 d。结果 模型组大鼠的全心重/体质量，左心室重/体质量均明显增加。 模型组大鼠血清中羟脯氨酸（HYP）含量显著增加。模型组大鼠心肌组织中总超氧化物歧化酶（SOD）含量与对照组相比显著 降低，而丙二醛（MDA）含量明显升高。结论 皮下注射异丙肾上腺素 14 d，可成功诱导大鼠心肌肥厚模型，为深入研究心肌 肥厚的确切机制奠定基础。

英文摘要：

Objective To establish a rat model of cardiac hypertrophy induced by isoproterenol （ISO）, and to study its basic characteristics. Methods Cardiac hypearophy was induced in rats with ISO. The model rats received subcutaneous injections of 5 mg/kg ISO every day for 14 days. Results The heart weight/body weight and left ventricular weight/body weight ratios in model rats were significantly increased. The serum hydroxyproline level was significantly increased, the superoxide dismutase level was significantly decreased, and the malondialdehyde level was sig- nificandy increased in model rats. Conclusion The rat model of cardiac hypertrophy is successfully created by subcutaneous injection of ISO for 14 days. This model can be used in study of the mechanism of cardiac hypertrophy.