中文摘要：

目的探讨青春期双酚A（BPA）暴露对小鼠认知功能和焦虑相关行为的损害效应及持续影响。方法60只选取4周龄ICR小鼠，随机均分为对照组、BPA（1、100mg／L）处理组。染毒4周后，于成年早期和成年期采用Morris水迷宫试验来检测空间学习和记忆能力，采用旷场试验、黑白巷试验、高架十字迷宫试验来检测探索和焦虑相关行为。结果BPA（100mg／L）处理组成年早期雌性小鼠的潜伏期和游泳距离显著延长（P〈0．05）。在旷场实验中，与对照组比较，BPA（1mg／L）处理组成年早期雌鼠的潜伏期差异有统计学意义（P〈0．05）；BPA（1mg／L）处理组年早期雌鼠和成年期雄鼠的站立次数较对照组显著减少（P〈0．05）。BPA（100mg／L）处理组成年期雌鼠的黑巷时间与对照组相比差异有统计学意义（P〈0．05）。结论青春期BPA暴露对小鼠空间学习和记忆功能的损害呈现显著性别差异，对雌鼠损害效应更为显著；青春期BPA暴露对小鼠探索与焦虑相关行为带来持续性影响。

英文摘要：

Objective To explore the effects of pubertal exposure to bisphenol A （BPA） on cognition and anxiety- related behavior in mice. Methods Randomly divided into three groups, mice were orally administered with either water or BPA （1 or 100 mg/L） from PND-28-PND-56. Morris Water Maze was performed to assess learning and memory. Open Field Test, Black-White Alley and Elevated Plus Maze were performed to assess exploration and anxiety-related behaviors. Results Pubertal .BPA exposure prolonged escape latency and swim distance in female mice during early adulthood （P 〈 0.05 ）, but not in male mice. In the Open-Field test, there was significant de- crease on latency in female mice during early adulthood. Compared with controls, rears were altered in females dur- t ing early adulthood and in males during adulthood （P 〈 0. 05 ）. In addition, significant difference was observed on time in black alley in females （ P 〈 0. 05 ）. Conclusion Pubertal BPA exposure impaired spatial learning and memory in a gender-specific manner. In addition, pubertal BPA exposure persistently disrupts exploration and anxi- ety-related behavior.