中文摘要：

目的 利用功能磁共振成像（fMRI）技术，研究焦虑症的神经病理机制。方法共20名受试者参加实验。广泛焦虑症患者10名，正常对照组10名。实验模式为Block Design，刺激材料通过听觉呈现。共进行两次fMRI实验。实验1情绪中性词与无词的空白对照交替，实验2威胁词与情绪中性词交替。随后对受试者进行焦虑状态量表测试。结果焦虑状态量表测试：实验1对照组量表分值为37±3，患者组57±4。实验2对照组分值为41±4，患者组为66±6。两次实验中，两组受试者分值差异均有统计学意义。fMRI结果：实验1患者组与对照组激活脑区大部分重叠。包括两侧颞上回（BA22／42）、颞中回（BA21）；左侧额下回（BA44／45）；双侧前运动区（BA6）；辅助运动区（BA6）及小脑半球。但患者组两侧颞上回激活强度（平均T值）强于对照组：左侧，P=0.051；右侧，P=0．035。且患者额外激活前额叶背外侧脑区（BA8／9）及两侧顶下小叶（BA39／40）。实验2患者组激活两侧颞上回（BA22／42）、颞中回（BA21）；两侧额下回（BA44／45）；左前额叶背外侧（BA46／10）；两侧顶下小叶（BA39／40）；两侧前运动区（BA6）；扣带回前部（BA8／24／32）；辅助运动区（BA6）。相同检验水平（P〈0，001，未校正），正常对照组无激活脑区。但是降低阈值后（P〈0，01），左侧扣带回后部（BA29／30）、左侧扣带回前部（BA24／32）及左侧顶下小叶（BA40）等脑区激活。结论广泛焦虑症患者的前额叶及颞叶可能存在功能异常，主要表现为对刺激加工的过度反应。

英文摘要：

Objective To explore the potential mechanism of generalized anxiety disorders （GAD）. Methods Ten GAD patients and 10 sex- and age-matched healthy persons underwent functional magnetic resonance imaging （fMRI） study in 2 stages by block design： auditory presentation of the stimulation task. In experiment 1 emotionally neutral words were given and then alternated with a no word period for 8 cycles. In experiment 2 emotionally neutral words and threat-related words were given alternately for 8 cycles. The subjects were asked to listen carefully and then judge their subjective feeling in mind. By the end of experiment they were asked to fill in a state anxiety inventory （STAI-S） so as to calculate the STAI-S scores. Results The mean STI-S score of the patients in the experiment 1 was 57±5, significantly higher than that of the healthy persons （ 37±3, P 〈 0.01 ） ; and the mean STAI-S score in the experiment 2 of the patients was 66±6, significantly higher than that of the healthy persons （41±4, P 〈0.01）. The fMRI findings showed that in the experiment 1 the activated cerebral regions of the 2 groups were mostly overlapped, including bilateral superior temporal gyri （BA22/42） and middle temporal gyri （BA21）, premotor areas （B46）, and supplementary motor areas （BA6）, and cerebellar hemisphere, and left inferior prefrontal gyrus （BA44/45）. However, the activation intensity levels （mean T values） of the bilateral superior temporal gyri of the patients were both significantly higher than those of the control （for the left side ： P = 0.051, and for the right side ： P = 0.035 ）. In addition, activation of the dorsal lateral prefrontal cortex （BA8/9） and bilateral inferior parietal lobules （BA39/40）. In the experiment 2 activation of brain areas could be seen only in the patients, including bilateral superior temporal gyri, middle temporal gyri, inferior prefrontal gyri, inferior parietal lobules, anterior motor areas, supplemental motor areas, and anterior