随着念珠菌易感人群和抗真菌药物使用的增加,念珠菌耐药形势越来越严峻.现从念珠菌属的菌种变迁、抗真菌药物应用、生物膜形成、药物作用靶酶基因过表达或突变等方面,对念珠菌耐药机制的研究进展加以综述.
With the increase in susceptible population of candida and widespread use of antifungal agents, the situation of candida re- sistance has become nlore and more serious. The resistance of candida albicans is reviewd in this paper, including alteration of candida species, application of antifungal agents, formation of biofilm, over-expression and mutation of the drug target enzymes, and so on.