中文摘要：

目的：观察电针对食源性肥胖大鼠的中枢性作用中,能否上调其弓状核内CART的表达。方法：对DIO大鼠进行电针刺激,3次/周,共4周。用免疫组化法检测弓状核内CART的表达,ELISA法检测血浆促肾上腺皮质激素（ACTH）的水平。结果：电针能减少DIO大鼠的体重和能量摄入,增加弓状核内CART的表达。束缚应激导致血浆ACTH水平升高,但是电针不会导致ACTH进一步增高。结论：电针能上调DIO大鼠CART的表达,进而引起摄食减少和体重减轻。这可能是电针治疗肥胖症的机制之一。

英文摘要：

Objective： To assess the central effect of electro-acupuncture （EA） on DIO rat and explore if EA up-regulate the expression of CART peptide in the arcuate nucleus （ARC） of the DIO rats. Methods ：After feeding with HIF diet for 14 weeks, the DIO rats received EA stimulation three times per week for 4 weeks. The expression of CART peptide in ARC was measured using immunohistochemistry. The plasma ACTH was measured with ELISA. Results： EA caused a reduction of both body weight and energy intake in DIO rats and increased the expression of CART peptide in ARC. The plasma ACTH was increased in response to restraint stress, but EA produced no further increase in ACTH levels. Conclusion： EA can up-regulate the expression of CART peptide to approach normal level, resulting in an inhibition of food intake and a reduction of body weight in DIO rats.