欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
根据生理药动学模型的特点,把非线性药动学模型转化为线性模型,并验证线性模型的精确性.在此基础上,构造估计药动学模型参数的目标函数,并利用非线性优化算法求解模型参数.仿真结果表明,我们的算法具有快速、精确和稳定的特点.给出了一种快速估计复杂生理药动学模型参数的方法,这为解决复杂生理药动学模型的参数估计问题提供了一种有效工具.
英文摘要：
According to the characteristics of the physiological pharmacokinetic model,the nonlinear pharmacokinetic model is converted to linear model,and the accuracy of the linear model is verified.Base on the linear model,the objective function of the parameters fitting is constructed,and the nonlinear optimization algorithm is used to solve model parameters.The simulation results show that our algorithm have the characteristics of rapid,accurate and stable.In this paper,a fast algorithm of parameters estimation for the complex physiological pharmacokinetic model is given,which provides an effective tool for complex physiological pharmacokinetic model parameter estimation problem.
同期刊论文项目
同项目期刊论文
Improved measurement of labile proton concentration-weighted chemical exchange rate (kws) with exper
Evaluation of the dependence of CEST-EPI measurement on repetition time, RF irradiation duty cycle a
Quantification of Choline Concentration Following Liver Cell Apoptosis using1 H Magnetic Resonance S
Human umbilical mesenchymal stem cell and its adipogenic differentiation profiling by nuclear magnet
Advanced nasopharyngeal carcinoma radiotherapy with volumetric modulated arcs and the potential role
Quantitative Proton Magnetic Resonance Spectroscopy of Human Precentral Gyrus and Hippocampus: Absol
Electrophysiological correlates of proactive interference in the 'Recent Probes' verbal working memo
Helical CT findings and clinicopathologic features in malignant gastrointestinal stromal tumors: the
MR Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment with N
Transarterial embolization using pingyangmycin lipiodol emulsion and polyvinyl alcohol for the treat
The 1.28 ppm biomarker: not specific for neural progenitor cells, but also in the mesenchymal stem c
Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment:
Extraction methods-based analysis of the human umbilical cord mesenchymal stem cells on 9.4 T high-r
1H-Proton Magnetic Resonance Spectroscopy Differentiates Dementia with Lewy Bodies from Alzheimer&rs
Quantitative chemical exchange saturation transfer (qCEST) MRI - RF spillover effect-corrected omega
期刊信息
位置：