中文摘要：

目的：探讨老年2型糖尿病患者血清中25-羟维生素D水平与其胰岛素13细胞功能的相关性，为老年2型糖尿病的预防和治疗提供理论基础。方法：选取2013年6月至2014年6月在我院接受治疗的老年2型糖尿病患者300例作为研究对象，另选取同期在我院参加体检的健康志愿者300例作为对照组。采用酶联免疫吸附法测定和比较两组研究对象血清中25-羟维生素D的含量，采用稳态模型胰岛素抵抗指数（HOMA-IR）、胰岛素敏感指数（LAI）、胰岛β细胞的功能指数（HBCI）以及空腹胰岛β细胞的功能指数（FBCD评估老年2型糖尿病患者的胰岛13细胞功能，并分析老年2型糖尿病患者血清中25．羟维生素D水平与上述参数的相关性。结果：老年2型糖尿病患者血清中25-羟维生素D水平为（10．2±0．9）ng／mL，显著低于正常对照人群（P〈0．05）；老年2型糖尿病患者血清中25-羟维生素D水平与HOMA-IR呈显著正相关（r=0．438，P=0．019），与IAI呈显著负相关（r=-0．392，P=0．023），与HBCI和FBCI无明显相关性（P〉0．05）。结论：老年2型糖尿病患者血清中的25．羟维生素D水平较低，与其胰岛素13细胞功能障碍有关，补充25-羟维生素D可能有助于老年2型糖尿病的治疗和预防。

英文摘要：

Objective： To investigate the correlation between the elderly in patients with type 2 diabetes and the insulin beta cells＇ function in order to provide a reference for the prevention and treatment of type 2 diabetes. Methods： 300 elderly patients with type 2 dia- betes who were treated in our hospital from June 2013 to 2014 were selected as the research group, and another 300 people Who had par- ticipate in the examination in our hospital were selected as the control group. The 25- hydroxyvitamin D, the homeostasis model assess- ment insulin resistance index （HOMA-IR）, the insulin sensitivity index （IAI）, the function of islet B cells （HBCI） and the fasting islet B cell function index （FBCI） were determined by the enzyme linked immunosorbent assay. And the function of islet B cells and insulin re- sistance were evaluated, and the correlation between the type 2 diabetes and the vitamin D levels were analyzed. Results： The 25- hy- droxyvitamin D level in the serum of patients with type 2 diabetes was （10.2± 0.9） ng/mL, which was significantly lower than that of the patients in the control group （P〈0.05）; The vitamin D was positively correlated with HOMA-IR （r=0.438, P=0.019）, and negatively corre- lated with IAI （r=-0.392, P=0.023）. There was no correlations between 25- hydroxyvitamin D and the HBCI and FBCI （P〉0.05）. Linear analysis showed that vitamin D was the influence factors of IAI and HOMA-IR. Conclusion： The 25- hydroxyvitarnin D level in the serum of elderly patients with type 2 diabetes could influence the progress of disease, and the supplyment of 25- hydroxy vitamin D could be effective for patients with type 2 diabetes.