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中文摘要：
利用冷冻干燥法制备了β-CaSiO3／丝素蛋白复合支架材料，经XRD和FTIR分析表明复合支架中丝素的结构主要以β-折叠为主；SEM分析显示材料孔隙分布均匀，孔连通性较好，孔径尺寸约为100～300μm。对支架的孔隙率和机械强度等性能进行了表征，研究表明复合支架的孔隙率为83％～87％，机械强度有较大提高。应用模拟体液浸泡实验研究了复合支架的体外生物活性，并用XRD、FESEM和EDS对试样表面进行了表征；结果显示，样品经模拟体液浸泡3天后，表面都能沉积出类骨羟基磷灰石（HA）层，β-CaSiO3的加入能加快复合支架表面沉积类骨HA的速度。研究结果显示β-CaSiO3／丝素蛋白复合支架材料有望作为强度较好的生物活性硬组织修复材料。
英文摘要：
β-CaSiO3/silk fibroin （SF） scaffolds with interconnected pore structures were prepared by freezing-dr- ying. XRD and FTIR analysis suggested that the SF was in β-sheet structure. The as-prepared β-CaSiO3/SF scaffolds showed good homogeneity and interconnected pores of about 100-300μm in diameter by SEM. The characterization of scaffolds were studied by means of porosity, mechanical properties and so on. Results showed that the composite scaffolds owned a higher ratio of mechanical intensity as compared to that of the pure SF porous scaffolds. Field emission scanning electron microscopy （FESEM） and energy-dispersive spectrometer （EDS） analysis on the scaffolds surface after immersion in SBF for 3days revealed that a hydroxyapatite layer （HA） was formed on the composite scaffolds. The speed of HA deposition were different between different materials, when β-wollastonite were added into SF scaffold,the speed of HA deposition was obviously accelerated. All these resuits indicated that β-CaSiO3/SF composite scaffold materials may be potential candidates as good compressive strength and bioactive scaffolds for hard tissue repair and tissue engineering applications.
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