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硫辛酸对2型糖尿病患者SOD、MDA及hs-CRP水平的影响

ISSN号：1008-0392
期刊名称：《同济大学学报：医学版》
时间：0
分类：R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
作者机构：[1]同济大学附属同济医院内分泌科,上海200065, [2]上海中医药大学附属普陀医院内分泌科,上海200062
相关基金：国家“八六三”高技术研究发展计划（2014AA022304）;上海市卫生局科研基金（20124256）

关键词： 2型糖尿病, α-硫辛酸, 超氧化物歧化酶, 丙二醛, 超敏C反应蛋白, type 2 diabetes mellitus, α-lipoic acid, SOD , MDA, hs-CRP

中文摘要：

目的探讨α-硫辛酸对2型糖尿病患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）及超敏C反应蛋白（hs-CRP）水平的影响。方法选择120例2型糖尿病患者按照治疗方法不同随机分为治疗组和对照组各60例,两组均给予常规降糖药物/胰岛素等治疗,治疗组在此基础上加用α-硫辛酸,连续治疗2周后评价患者血清SOD、MDA、hs-CRP水平变化,治疗结束后3个月再次复查患者血清SOD、MDA、hs-CRP水平并对比其变化。结果治疗14 d后治疗组SOD、MDA、hs-CRP水平明显改善,与治疗前及对照组比较差异具有统计学意义（P〈0.05）;治疗结束后3个月两组患者SOD、MDA、hs-CRP含量的差异具有统计学意义（P〈0.05）。在治疗组中,治疗14 d后与治疗后3个月相比,SOD、MDA的差异具有统计学意义（P〈0.05）,hs-CRP的差异不具统计学意义（P〉0.05）。结论α-硫辛酸在2型糖尿病的治疗中有利于改善机体氧化应激反应、降低炎性递质水平,对于改善预后、延缓相关并发症的发生发展具有重要意义。

英文摘要：

Objective To investigate the influence of α-lipoic acid on serum SOD, MDA and hs- CRP levels in type 2 diabetic patients. Methods One hundred and twenty type 2 diabetic patients were randomly divided into two groups with 60 cases in each. Patients in both groups received conventional hypoglycemics/insulin therapy, and α-lipoic acid was added in patients of observation group. Serum SOD, MDA and hs-CRP were determined before treatment and 2 weeks and 3 months after treatment. Results After 2 weeks of treatment, serum SOD was significantly increased, serum MDA and hs-CRP were significantly decreased in α-lipoic acid group compared to same group before treatment and the control group after treatment （ all P 〈 0.05 ）. There were significant differences in serum SOD andMDA levels of a-lipoic acid group between those at 2 weeks and at 3 months after treatment （P 〈 0. 05）, but no significant difference in hs-CRP levels （P 〉 0.05 ）. Conclusion α- lipoic acid can reduce the oxidative stress response and inflammatory mediator levels in type 2 diabetic patients receiving conventional treatement.

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