中文摘要：

当前腧穴敏化的成像研究相对不足,尤其在组织微循环层次上难以深入。光声成像具备高对比度、高探测深度、对组织功能特性敏感等特点,是微循环成像领域的主流技术与前沿热点之一。本文简要介绍了光声成像,并从结构及功能方面综述了微循环的光声成像研究进展。光声成像能够对兴趣组织一定深度范围内的微循环结构进行3D、高空间分辨率成像及量化评价,同时能够对目标血管的总血红蛋白浓度及其氧合水平、血流速、氧代谢水平、微血管舒缩运动、血流动力学等进行实时、动态监测。在此基础上,本文结合当前腧穴微循环敏化的成像研究进展,展望了光声成像在腧穴微循环敏化成像研究中的应用。光声成像与腧穴敏化成像研究的实际需要相符合,在敏化态腧穴局部微循环与腧穴的中枢敏化成像上具有应用潜力,有望进一步明确敏化态腧穴微循环的特征性改变,丰富腧穴中枢敏化的具体内涵。

英文摘要：

Research on the imaging of acupoint sensitization is inadequate, especially at the microcirculation level. Photoacoustic imaging is one of the main techniques used in microcirculation imaging, and has the characteristics of high contrast, high detection depth and high sensitivity for tissue function. In the present paper the authors briefly introduce photoacoustic imaging and review research advances in photoacoustic imaging of microcirculation from the aspects of structure and function. The photoacoustic technique can three-dimensionally image and quantitatively examine microcirculation structure to the depth of interest tissues with high spatial resolution, and can dynamically measure total hemoglobin concentration and its oxygenation level, blood flow velocity, oxygen metabolism level, vasoconstriction, vasodilation, and hemodynamics of a target vessel in real time. Based on these factors, the prospects of the application of photoacoustic imaging are debated. The authors propose that photoacoustic imaging is appropriate for research on the sensitization of microcirculation in acupoints and can be applied to sensitized acupoints locally or in the brain, which is expected to further determine characteristic changes in the microcirculation of sensitized acupoints and enrich the specific connotation of the central sensitization of acupoints.