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低氧环境下运动对大鼠血清睾酮、皮质酮浓度及其比值的影响
  • 期刊名称:第二军医大学学报
  • 时间:0
  • 页码:710-712
  • 语言:中文
  • 分类:R872.4[医药卫生—运动医学;医药卫生—临床医学]
  • 作者机构:[1]上海体育学院运动科学学院运动生化教研室,上海200438
  • 相关基金:国家自然科学基金(30870349); 上海市教委科研创新项目(09yz304); 上海市重点学科建设项目(S30802)
  • 相关项目:大鼠海马神经发生对低氧适应及其机制研究的动物模型建立
中文摘要:

目的观察不同低氧浓度环境训练后大鼠血清睾酮(testosterone,T)、皮质酮(corticosterone,C)的浓度及T/C的变化,为确立适宜的低氧训练模式提供实验依据。方法 SD大鼠60只,随机分为安静对照组(C)、常氧运动组(E)、15%氧浓度对照组(15C)、15%氧浓度运动组(15E)、11%氧浓度对照组(11C)和11%氧浓度运动组(11E),每组10只,运动方式为跑台运动。采用ELISA方法检测大鼠血清中T和C的浓度。结果 (1)11C组T浓度低于C组(P〈0.05);11E组T浓度低于E组(P〈0.01);(2)E组大鼠血清C浓度高于C组(P〈0.05);11E组C浓度低于E组(P〈0.01);15E组C浓度低于E组(P〈0.05);(3)11C组T/C值低于C组(P〈0.05)。结论 11%氧浓度对T/C的平衡可能带来负面影响,但运动可一定程度代偿低氧带来的不利影响;15%氧浓度未对大鼠T/C的平衡产生影响。

英文摘要:

Objective To observe the changes of serum testosterone(T),corticosterone(C),and testosterone/corticosterone(T/C) values in SD rats trained under different hypoxic conditions,so as to provide an experimental evidence for correct hypoxia training.Methods A total of 60 SD rats(8-week-old) were randomly divided into 6 groups: normal control(C),normal exercise(E),15% oxygen control(15C),15% oxygen exercise(15E),11% oxygen control(11C),and 11% oxygen exercise(11E) groups.The animals received treadmill running for exercise,and the levels of serum T and C were examined by ELISA.Results(1) Testosterone level in group 11C was significantly lower than that in group C(P0.05);testosterone level in group 11E was significantly lower than that in group E(P0.01).(2) Corticosterone level in group E was significantly higher than that in group C(P0.05);corticosterone levels in group 11E and 15E were significantly lower than that in group E(P0.05).(3) The ratio of T/C in group 11C was significantly lower than that in group C(P0.05).Conclusion The 11% oxygen may cause negative effects on the T/C balance,but exercise may compensate the negative effect to some extent;the 15% oxygen causes no noticeable influence to T/C balance.

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