中文摘要：

目的比较西酞普兰合并改良电休克治疗（MECT）与西酞普兰单一治疗抑郁发作的效果以及对认知功能的影响。方法采取临床试验研究,收集符合《国际疾病分类第（10版）》（ICD-10）抑郁发作诊断标准的患者80例,随机分为西酞普兰合并MECT组及西酞普兰单药组各40例。合并MECT治疗组需进行为期2周、共8次MECT治疗。两组均经过为期4周的治疗。在MECT治疗前及治疗2、4周末采用汉密尔顿抑郁量表（HRSD）和威斯康星卡片分类测验（WCST）对两组疗效及认知损害进行测评。结果治疗前两组HRSD评分比较差异无统计学意义（t=0.51,P〉0.05）。治疗2周末两组间HRSD评分差异有统计学意义（t=2.66,P〈0.05）;疗程结束时两组HRSD评分差异无统计学意义（t=1.81,P〉0.05）。合并MECT组中WCST中的总应答数（ra）、完成分类（cc）、错误应答数（re）、概念化（rf%）、非持续错误（nrpe）及学习到学会（l-l%）等项在治疗2周后较治疗前差（P〈0.05）;在治疗4周后较治疗前好（P〈0.05）;其它各指标治疗前后差异均无统计学意义（P均〉0.05）。结论西酞普兰合并MECT治疗较西酞普兰单药能更快起效,而且持续疗效稳定。合并MECT治疗患者可出现短期、可逆的认知功能损害,但提示远期预后较好。

英文摘要：

Objective To compare the clinical response and cognitive dysfunction of depressive inpatients treated with citapramil complicated with modified electro - convulsive therapy（MECT）and citapramil only. Methods According the clinical trial,80 inpa-tients matched with the criteria of International Classification of Diseases tenth edition（ICD - 10）about depressive disorder were en-rolled,and divided randomly into both groups of citapramil complicated with MECT and citapramil only. After 8 times treatment of MECT and totally 4 - week treatment,the response and cognitive dysfunction were compared at pre - and post - treatment of MECT for 2 weeks and 4 weeks separately between the two groups with Hamilton Rating Scale for Depression（HRSD）and Wisconsin Card Sor-ting Test（WCST）. Results At the baseline,the scores of HRSD were not different between both of groups（t = 0. 51,P ﹥ 0. 05）. There was statistics difference between both of groups after 2 - week treatment（t = 2. 66,P ＆lt; 0. 05）. In the group of complicated with MECT,scores of ra,cc,re,rf% ,nrpe,and l - l% in WCST were decreased significantly after 2 - week treatment,but improved af-ter 4 - week treatment and better than the baseline（t = 1. 81,P ﹥ 0. 05）. Other items do not show the differences（P ﹥ 0. 05）. Con-clusion Citapramil with MECT can obtain the effects of treatment faster than with citapramil only,moreover,the effects can be main-tained. The patients complicated with MECT will have a short - term,and reversible cognitive dysfunction.