中文摘要：

人类许多肿瘤的发生都是基因异常调节的结果，神经肿瘤也不例外。研究表明，某些与发育相关的基因发生突变或调节异常可能会导致神经肿瘤的发生，最近发现的一种原癌基因Bmi-1（Blymphoma MO—MLV insertionregion 1，Bmi-1）就是其中之一，它不仅参与胚胎的发育、多种干细胞的维持和自我更新，而且其过度表达可导致包括神经肿瘤在内的多种肿瘤的形成；Bmi-1缺失小鼠可表现为多种异常，如共济失调、血液疾病及神经疾病，表明Bmi-1具有多种生物学功能。

英文摘要：

Polycomb group proteins Bmi- 1 is the core subunits of the PRC1 complex, and also plays important roles in the regulation of neural development. This review introduces the construction of Bmi - 1 and the recent study for Bmi - 1 in the nervous system development and .tumor generation. The important roles of Bmi - 1 for sustain of the neural stem cell proliferation, regulation mechanism of neural development and tumor generation are discussed.