中文摘要：

采用反相乳液悬浮法制备壳聚糖／β-TCP复合微球，在乳化前通过向壳聚糖／β-TCP溶液中加入戊二醛溶液的方法引入初交联工艺，目的在于提高复合微球的交联强度。通过动态流变学方法研究发现，加入交联剂后，壳聚糖溶液的粘度随搅拌时间的延长而增加，最后形成凝胶。根据所需微球的形貌及球径要求选择适当粘度的壳聚糖／β-TCP溶液作为水相进行乳化，结合所制备微球的形貌特点发现，在加入3m10．5％（质量分数，下同）的戊二醛溶液，初交联时间为10min时，制得的微球形貌最佳，其球径在100-450μm范围内且分布均匀。

英文摘要：

Chitosan/β-TCP composite microspheres were fabricated by solid-in-water-in-oil （s/w/o） emulsion cross-linking method. In order to improve the cross-linking strength of the microspheres, the preparatory cross-linking procedure was introduced by adding dilute glutaraldehyde solution into chitosan/β-TCP slurry before emulsion in liquid paraffin. By rheological measuring, the kinetics of the initial stage of gelation in chitosan/β-TCP slurry containing glutaraldehyde was studied. When the procedure parameters of preparatory cross-linking were 3ml, 0.5%wt, and 10min, the optimal microspheres, which possess good spherical shape, and about 100μm -450μm of diameter, could be obtained.