中文摘要：

Lipocalin 2 (LCN2 ) ，作为嗜中性的联系 gelatinase 的 lipocalin (NGAL ) 知道的多功能的能分泌的蛋白质，在许多癌症被表示。然而，很少在肺腺癌的发展对 NGAL 的生物功能被知道。在现在的学习，我们首先发现那 NGAL 表情在人的肺腺癌纸巾是起来调整的。另外， NGAL 表示的弄空减少了房间增长和导致的房间 apoptosis 的能力。而且与 N-acetylcysteine 的增加，反应的氧种类(ROS ) 的 scavenger， NGAL 弄空是足够的由通过原子因素的抑制产生 ROS 引起肺腺癌细胞的 apoptosis，这被发现 E2 相关的因素 2/heme oxygenase-1 抗氧化剂小径。最后，人的肺腺癌的生长上的 NGAL 下面规定的效果在 BALB/c 裸体老鼠被决定。这些调查结果证明 NGAL 可以是为有肺腺癌的病人的一个潜在的治疗目标。

英文摘要：

Lipocalin 2 （LCN2）, a multifunctional secretory protein known as neutrophil gelatinase-associated lipocalin （NGAL）, is expressed in a variety of cancers. However, little is known about the biological functions of NGAL in the development of lung adenocarcinoma. In the present study, we primarily found that NGAL expression was up-regulated in human lung adenocarcinoma tissues. Additionally, depletion of NGAL expression decreased the ability of cell proliferation and induced cell apoptosis. Furthermore, with the addition of N-acetylcysteine, a scavenger of reactive oxygen species （ROS）, it was found that NGAL depletion was sufficient to cause apoptosis of lung adenocarcinoma cells by generating ROS through the inhibition of the nuclear factor E2-related factor 2/heine oxygenase-1 anti-oxidant pathway. Finally, the effect of NGAL down-regulation on the growth of human lung adenocarcinoma was determined in BALB/c nude mice. These findings demonstrate that NGAL may be a potential therapy target for patients with lung adenocarcinoma.