中文摘要：

微小RNA是一类真核细胞中广泛存在的内源性转录后调控分子,其在细胞的增殖、分化、凋亡、迁移等过程中发挥了重要的调控作用。皮肤创伤修复涉及复杂的细胞与分子的相互作用网络。近年来研究表明micro RNAs在皮肤创伤修复中发挥调控作用,引人关注。miR-21作为重要的癌基因是目前研究的最多的miRNAs分子之一,其在皮肤创伤修复中的作用研究也越来越受到重视。研究表明miR-21参与了细胞增殖与迁移、炎症反应、血管生成和细胞外基质合成等重要修复相关事件的调控。因此,阐明miR-21分子在正常皮肤创伤愈合中的作用,厘清miR-21表达失调在修复不足和修复过度中的功能,将深化我们对于皮肤创伤愈合基本理论的认识,并为促进创面愈合与防治修复不足和过度提供潜在的治疗靶点。本文就miR-21分子在正常皮肤创伤修复、慢性难愈性创面和增生性瘢痕中作用的研究进展进行综述展望。

英文摘要：

Micro RNA is a kind of endogenous post-transcriptional regulatory molecules extensively existed in eukaryotes, which plays an important role in cell proliferation, differentiation, apoptosis and migration. Cutaneous wound healing is one intricate pathophysiologic process involving interaction among cells and molecules. Recently, many studies indicated that micro RNAs had important functions in regulating skin wound healing and attracting more and more attention. MiR-21 is an important oncogene and one of the most investigated mi RNAs and its role during skin wound healing has been paid more attention. Many studies indicated that miR-21 is involved in regulation of repair-related important events such as cell proliferation, migration, inflammation, angiogenesis,synthesis of extracellular matrix and so on. So, clarifying the role of miR-21 during normal skin wound healing and exploring its potential function in the formation of both non-healing wounds and hypertrophic scar, will deepen our basic knowledge of cutaneous wound healing and may provide possible molecular target of gene therapy. And this article will review and outlook the research advance of miR-21 in skin wound healing, chronic non-healing wound and hypertrophic scar.