目的:探讨复方丹参片防治冠心痛的可能机制。方法:高血脂大鼠采用球囊损伤法建立动脉损伤模型,观察复方丹参片对大鼠血脂、主动脉病理学等指标的影响。结果:复方丹参片可降低内膜与中膜比值、减轻主动脉病理性斑块的形成,但对血脂含量无明显影响。结论:复方丹参片防治冠心病可能与其抗动脉内膜损伤等作用有关。
Objective:To discuss the mechanism of Fufang Danshen tablets on preventing and treating coronary heart disease. Methods : High lipid rats were balloon injuried on the left carotid artery after 4 weeks of a high cholesterol diet, blood lipids and morphometric analysis of the aorta artery were observed after treated 4 weeks by Fufang D anshen tablets. Results : Fufang Danshen tablets can reduce the rats aorta artery neointimal hyperplasia induced by balloon injury,but no obvious effect on blood lipids. Conclusion:Anti artery neointimal hyperplasia is the mechanism of Fufang Danshen tablets on preventing and treating coronary heart disease.