介绍了SC—CO2条件下药物插嵌的机理、过程以及插嵌过程中助溶剂的研究情况,阐述了目前SC—CO2条件下药物插嵌的在线检测方法,主要包括称重法、测量体积法以及光谱检测法,分析了影响在线检测的因素,并且综述了目前有关药物插嵌以及在线检测的研究现状。
The mechanism and process of pharmaceutical impregnation, as well as cosolvent, in supercritical CO2 condition are introduced. On-line detection methods, especially weight measuring, volume measuring and in-situ spectroscopy are presented, The influence factors are also analyzed. The research progress in these fields is reviewed.