中文摘要：

PEX11基因家族成员是参与过氧化物酶体增殖调控的关键因子,文章利用生物信息学方法对26种代表性真菌的PEX11基因家族成员进行了检索和进化分析。研究发现：（1）26种真菌中共有66个可能的PEX11p。酵母类真菌有1个或2个PEX11p,而大多数丝状真菌中包含2到3个,其中子囊菌中PEX11p的个数偏多,个别种类达到5个;（2）真菌PEX11p可分为3类,大多数真菌含有类型Ⅰ和类型Ⅲ的PEX11p,类型Ⅱ是盘菌亚门真菌所特有的,可能与类型Ⅰ和类型Ⅱ在功能上有冗余;（3）通过MEME分析,发现PEX11p含有多个保守区域,其中C末端的Motif8具有很高的保守性,推测可能对PEX11p发挥功能具有重要作用。文章对进一步研究真菌PEX11p的进化与功能以及过氧化物酶体的增殖具有重要意义。

英文摘要：

The family members of PEXll are key factors involved in regulation of peroxisome proliferation.Sixty-six PEX11p candidates ofPEXll gene family from26 representative fungal species were obtainedand analyzed by bioinfor-matic strategies.In most filamentous fungi,2 or 3 potential PEXllps were found,in contrast with 1 or 2 in yeast species.Compared with other fungal species,the Ascomycetes tend to have more PEX（）ps,and even 5 in several individuals.The data ofphylogenetic analysis and protein structure indicated that all of the PEX11ps were divided into 3groups：Ⅰ,Ⅱ,and Ⅲ.The members of group Ⅰ and grouplIIexisted in most species,while those in group II were found only in Pezizomycotina.By MEME analysis,5-6 conserved motifs were found in each PEXllps.Among them,motif 8 in C-terminal had the most conservation,indicating that this motif probably plays a key role in maintaining the proper functionof PEX1 lp.