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血肌酐与胱抑素C在慢性肾脏病诊断及评估肾功能损伤程度中的应用
  • ISSN号:2095-140X
  • 期刊名称:《解放军医药杂志》
  • 时间:0
  • 分类:R446.1[医药卫生—诊断学;医药卫生—临床医学] R692[医药卫生—泌尿科学;医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]咸阳市中心医院检验科,陕西咸阳721000, [2]新乡市中心医院检验科,河南新乡453000
  • 相关基金:国家高技术研究发展计划子课题(2014AA022304)
中文摘要:

目的 探讨血肌酐(serum creatinine,Scr)与胱抑素C(cystatin C,Cys-C)在慢性肾脏病(chronic kidney disease,CKD)诊断及评估肾功能损伤程度的应用价值。方法 选取咸阳市中心医院2014年6月—2016年6月收治的173例CKD患者为观察组,并选取同期体检的173例健康人为对照组。分析比较两组血清Scr与Cys-C水平,观察组Scr与Cys-C阳性率,Scr与Cys-C诊断效能,观察组不同CKD分期血清Scr与Cys-C水平。结果 观察组血清Scr和Cys-C水平均显著高于对照组(P〈0.01)。观察组Cys-C阳性率显著高于Scr(P〈0.01)。ROC曲线分析显示,CysC的曲线下面积、特异性及比数积均明显高于Scr(P〈0.05)。观察组血清Scr和Cys-C水平均随CKD分期的增加而呈逐渐上升趋势(P〈0.01)。结论 Scr与Cys-C均具有诊断CKD与评估肾功能损伤的价值,但Cys-C在特异性与准确度上更高,故可作为诊断CKD患者肾功能的可靠指标。

英文摘要:

Objective To investigate application value of serum creatinine (Scr) and cystatin C (Cys-C) in diagnosis and evaluation of degree of renal function damage in patients with chronic kidney disease (CKD). Methods A total of 173 CKD patients admitted during June 2014 and June 2016 were selected as observation group, and other 173 healthy people taking physical examination at the same time were selected as control group. Set and Cys-C levels were an- alyzed and compared in two groups. In observation group, positive rates of Scr and Cys-C, diagnostic abilities of Scr and Cys-C, Scr and Cys-C levels in patients with different CKD stages were also analyzed and compared. Results Serum levels of Scr and Cys-C in observation group were significantly higher than those in control group (P 〈 0. 01 ). Cys-C positive rate was significantly higher than that of Ser in observation group (P 〈 0.01 ). ROC curve analysis showed that val- ues of area under the curve, specificity and odds plot of Cys-C were significantly higher than those of Scr ( P 〈 0.05 ). Serum levels of Scr and Cys-C were gradually increased with increasing CKD stage in observation group (P 〈 0. 01 ). Conclusion Both Scr and Cys-C can diagnose and evaluate renal function damage in CKD patients, but Cys-C has better specificity and accuracy, and therefore it can be used as a reliable indicator for diagnosing renal function in CKD patients.

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期刊信息
  • 《解放军医药杂志》
  • 中国科技核心期刊
  • 主管单位:北京军区联勤部卫生部
  • 主办单位:北京军区医学科学技术委员会
  • 主编:赵会懂
  • 地址:石家庄市中山西路398号
  • 邮编:050082
  • 邮箱:jfjyyzz@126.com
  • 电话:0311-87978599
  • 国际标准刊号:ISSN:2095-140X
  • 国内统一刊号:ISSN:13-1406/R
  • 邮发代号:18-232
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊
  • 被引量:7516