中文摘要：

目的探讨冬虫夏草菌粉（百令胶囊）对Graves病（GD）患者机体免疫状态的调理作用。方法 84例GD患者随机分为对照组（n=42）和治疗组（n=42）,对照组根据甲状腺功能水平给予适量甲巯咪唑,治疗组则在相似治疗剂量的基础上加用百令胶囊（2 g/次,3次/d）,连续6个月。观察入组时,服药1个月、3个月及6个月后受试者的甲状腺功能（FT3、FT4、TSH）、甲状腺过氧化物酶抗体（TPO-Ab）水平、抗TSH受体抗体（TR-Ab）水平以及T淋巴细胞亚群（CD3~＋,CD4~＋,CD8~＋及CD4~＋/CD8~＋）水平。结果 （1）治疗6个月后,两组甲状腺功能均较治疗前下降,差异无统计学意义（P〉0.05）;（2）治疗组的自身抗体TPO-Ab及TR-Ab水平较治疗前均有下降（P均〈0.001）;与对照组相比,治疗组抗体滴度显著下降（P均〈0.001）;（3）疗程可影响TR-Ab的水平,但对TPO-Ab水平无明显作用;（4）治疗6个月后,与对照组相比,治疗组的CD4~＋细胞水平下降（P=0.003）,CD8~＋细胞水平上升（P=0.046）,CD4~＋/CD8~＋比值下降（P=0.027）。结论百令胶囊不仅可以明显改善GD患者体液免疫功能,即降低甲状腺自身抗体TPO-Ab和TR-Ab水平,同时还可以调节细胞免疫水平即T细胞亚群比例,使CD4~＋/CD8~＋比值下降,从而使GD患者整体自身免疫紊乱状况得到有效改善。

英文摘要：

Objective To investigate the regulating effect of Bailing capsule on autoimmunity in patients with Graves＇disease（GD）.Methods Eighty-four patients with GD were divided into the control group（n=42）,which was treated with methimazole,and the experimental group（n=42）,which was treated with methimazole combined with Bailing capsule（2 grams each time,three times a day） for 6 months.The levels of thyroid function（FT3,FT4,TSH）,antithyroid peroxidase antibody（TPO-Ab）,thyrotrophin receptor antibody（TR-Ab）,and subsets of T-lymphocytes（CD3~＋,CD4~＋,CD8~＋ and CD4~＋/CD8~＋） were measured before treatment,and 1 months,3 months,and 6 months after treatment.Results（1） The thyroid function of the two groups had no statistical difference after treatment（P〉0.05）;（2） After treatment,the levels of TPO-Ab and TR-Ab in the experimental group were lower than pretherapy（P〈0.001）;compared with the control group,the Abs also decreased significantly（P〈0.001）;（3） course of treatment could influence the level of TR-Ab;（4） After six months of treatment,the CD4~＋ T cells in the experimental group decreased（P=0.003）,CD8~＋ T cells increased（P=0.046）,and CD4~＋/CD8~＋ decreased（P=0.027） markedly than the control group.Conclusion The Bailing capsule can effectively decrease the levels of TPO-Ab and TR-Ab in GD patients,and regulate the cellular immune functions,accordingly improve the immune disorder.