中文摘要：

脱氢枞胺经乙酰化、硝化、还原制得12-氨基-N-乙酰脱氢枞胺,再与相应的取代苯甲醛反应制得一系列脱氢枞胺衍生物的Schiff碱6a～6e。选用Hey-1B卵巢癌细胞株测定了目标物的体外抗肿瘤活性,结果显示6a～6e体外对Hey-1B卵巢癌细胞株均有一定活性。

英文摘要：

Dehydroabietylamine underwent acetylation,nitration and reduction to give 12-aminoN-acetyldehydroabietylamine,which reacted with substituted benzaldehydes to obtain five Schiff＇s bases of dehydroabietylamine derivative（6a～6e）.Their antitumor activities on Hey-1B ovarian cancer cell line were tested.The results showed that 6a～6e had inhibitory effects on Hey-1B ovarian cancer cell line in vitro.