中文摘要：

目的：通过腹腔注射链脲佐菌素（STZ）建立2型糖尿病的SD大鼠模型,观察给药剂量、给药次数对大鼠成模率、死亡率的影响。方法：将60只雄性SD大鼠随机分为正常对照组（N组）及造模组（A、B、C组）,予高糖、高脂饲料喂养8周后,造模组分别给予链脲佐菌素（STZ）20 mg/kg单次腹腔内注射（A组）、20 mg/kg连续2 d腹腔内注射（B组）及30 mg/kg单次腹腔内注射（C组）,然后测空腹血糖。结果：A组成模率较低（33.3%）,死亡率0%;B组成模率较高（66.7%）,死亡率13.3%;C组成模率高（100%）,死亡率高（60.0%）。结论：高糖、高脂饲养8周后联合小剂量STZ 20mg/kg连续2 d腹腔内注射组SD大鼠成模率较高,死亡率较低。

英文摘要：

Objective：The SD rats model of type 2 diabetes mellitus were established by intraperitoneal injection of streptozotocin（STZ）,and we observed the effects of dose and number of administration on the rate of mold formation and mortality in rats.Methods：60 male SD rats were randomly divided into the normal control group（N） and the model group of A-C group.After feeding high glucose and high fat diet for 8 weeks,the model group was given streptozotocin（STZ） 20 mg/kg single intraperitoneal injection（the A group）,20 mg/kg continuous two days intraperitoneal injection（the B group） and 30 mg/kg single intraperitoneal injection（the C group）,then fasting glucose was measured.Results：In A group,the molding rate was low（33.3%）,and the mortality rate was 0%.In B group,the molding rate was higher（66.7%）,and the mortality rate was 13.3%.In C group,the molding rate was high（100%）,and the mortality rate was high（60%）.Conclusion：After feeding high glucose and high fat diet for 8 weeks,combined with small dose of STZ 20 mg/kg continuous two days intraperitoneal injection,the molding rate of SD rats was higher,and the mortality rate was lower.