转录因子E2相关因子2-抗氧化反应元件(Nrf2-ARE)信号通路是机体抗氧化过程中的重要调节途径。Nrf2-ARE信号通路在抗氧化活化过程中受亲核物质、氧化应激因子、蛋白激酶C(PKC)、丝裂原活化蛋白激酶(MAPKs)、磷脂酰肌醇激酶(P13K)、胰腺内质网激酶(PERK)等因子调控。Nrf2-ARE信号通路的活化可以保护细胞的酶类和抗氧化物处于基础表达水平,细胞处于稳定状态。本文就Nrf2-ARE信号通路调节机体抗氧化的机理进行综述。
The transcription factor E2-related factor 2 ( Nrf2 ) -antioxidant response elements (ARE) signaling pathway has an important regulate function in the process of the antioxidant effects. Nrf2-ARE signaling pathway is regulated by series of adjustment factors in the process of activation of antioxidant effects, such as nucleophilic substances, oxidative stress factor, protein kinase C (PKC), mitogen-activated protein kinase (MAPKs) , phosphatidylinositol kinase (PI3K) and pancreatic endoplasmic network kinase (PERK). The activation of Nrf2-ARE signaling pathway can maintain enzymes and antioxidants in the basal expression levels, and the cells in a stable state. This review summarized the mechanism of Nrf2-ARE signaling pathway in regulating antioxidant effects.