中文摘要：

N-乙酰基-丝氨酰-天门冬氨酰-赖氨酰-脯氨酸（AcSDKP）是一种具有抗器官纤维化作用的由四个氨基酸构成的短肽。正常生理状态下，存在于人的血浆和淋巴系统内。近年研究发现AcSDKP能够抑制诸多器官如心、肺、肾、肝的纤维化。其中可以抑制器官内的靶细胞（如心脏成纤维细胞、肺成纤维细胞、肾小球系膜细胞和肝星状细胞）的增殖和胶原蛋白的合成或表达，通过信号转导系统的调节抑制靶器官内胶原的沉积，减轻致病因素导致的器官纤维化的程度。

英文摘要：

N-acetyl-seryl-aspartly-lysyl-proline （AcSDKP） is a kind of anti- fibrosis effects of short peptides, which is normally present in human plasma and circulating mononuclear cells. Recent studies found that AcSDKP was involved in some organ＇ s fibrosis, such as heart, lung, kidney and liver. AcSDKP could inhibit the target cells such as cardiac fibro- blasts, lung fibroblasts, glomerular mesangial cells and hepatic stellate cells proliferation and collagen synthesis and expres- sion. Through a variety of mechanisms including extracellular signal transduction AcSDKP can inhibit a target organ within the collagen deposition and reduce the causative factors leading to organ fibrosis.