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中文摘要：
以腺苷为原料,利用Mitsunobu反应分别采用三步法（总收率69.6%）和一步法（收率68.4%）合成了5′-脱氧-5′-乙酰硫代腺苷,其结构经1HNMR和MS表征。Mitsunobu反应一步法对腺苷5′-OH有较高的化学选择性,并根据这一事实提出了可能的反应机理。
英文摘要：
5′-Acetylthio-5′-deoxynucleoside was synthesised from adenosine by Mitsunobu reaction of three steps（total yield of 69.6%） and one step（yield of 68.4%）,respectively.The structrue was characterized by 1H NMR and MS.The possible reaction mechanism was provided according to the fact that 5′-OH exhibited more selective replaced by acetylthio group in the one step method.
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