中文摘要：

干细胞衰老理论认为，组织器官特异的成体干细胞随着衰老出现功能性衰退，从而导致组织器官生理功能的衰退甚至衰老相关疾病的发生．表观遗传机制通过精密调控基因表达，在成体干细胞的衰老过程中发挥着重要作用．近年来，机体衰老过程中成体干细胞的表观遗传调控已经成为衰老研究的热点．本综述主要总结了衰老过程中成体干细胞命运的表观遗传调控，并详细介绍了DNA甲基化与组蛋白共价修饰在成体干细胞衰老中的作用，以期为深入认识衰老本质、实现健康长寿提供启示．

英文摘要：

Tissue and organ-specific adult stem ceils degenerate progressively with age, resulting in compromised tissue homeostasis and occurrence of aging-associated diseases. Epigenetic mechanisms play a key role in controlling individual as well as stem cell aging by the regulation of global and/or specific gene expression. Here, we summarize the recent findings on how epigenetic modifications especially DNA methylation and histone modifications regulate stem cell fate during aging, which may open a promising avenue towards achieving the goal of healthy aging.