中文摘要：

基因变异是白念珠菌产生唑类药物耐受性的主要原因之一。不同类型的变异在白念珠菌耐药性发生进程中起着不同程度的推动作用。其中ERG系列基因突变,主要是影响麦角甾醇合成通路;而白念珠菌CDR1、MDR1的调控因子TAC1、Mrr1突变影响白念珠菌药物外排泵蛋白的表达水平。此外,基因拷贝数的变异也逐渐受到人们的重视。因此,白念珠菌的耐药相关基因变异研究对于探讨白念珠菌耐药机制具有积极的意义。

英文摘要：

Gene mutation of Candida albicans is one of the main causes for azole drug resistance.Different types of variation play different roles in promoting the process of drug resistance.ERG series of gene mutations primarily affect the ergosterol synthesis pathway.When the regulatory factors TAC1 for CDR1 gene and Mrr1 for MDR1 gene generate mutations,the expression level of drug efflux pump protein in Candida albicans may be changed.In addition,gene copy number variation is also gaining attention.Therefore,the research of mutation resistance-associated genes has a positive meaning to explore the mechanism of drug resistance in Candida albicans.