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中文摘要：
瘦素具有抑制胰岛素的分泌和表达、拮抗胰岛β细胞的调亡、调节骨骼肌和肝细胞糖代谢的重要病理生理功能。本文将对人体内瘦素抵抗现象和瘦素基因多态性与2型糖尿病的相关性以及它们对2型糖尿病药物治疗的影响作一综述。
英文摘要：
Leptin has many important pathophysiological effects, such as inhibiting insulin secretion and expression, constraining pancreatic β cell apoptosis and controlling glucose metabolism through skeletal muscle cell and hepatic cell. This review summarizes the phenomena of leptin resistance and leptin gene polymorphismin vivo, particularly emphasizing its correlation with type 2 diabetes and drugs clinical effective.
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