脂质体作为药物载体具有提高药物疗效、减轻药物不良反应及靶向作用的特点,常用制备方法主要有薄膜分散法、逆相蒸发法、注入法、超声波分散法等。在制备含药脂质体时,根据药物被装载的机理不同,又可分为被动载药法(Passive Loading)与主动载药法(Active Loading)两大类。
Describes the current commonly used two types of liposome preparation methods: Passive drug-loading method and active drug-loading method, ann to compare their advantages and disadvantages. Passive drug-loading method is suitable for fat-soluble drugs with strong, Encapsulation efficiency high and difficult to reveal; And active drug-loading method is suitable for two pro-drug.