中文摘要：

肺纤维化是严重危害人类健康的公共卫生问题，诊断后中位生存期仅为2～3年，目前已有的抗肺纤维化药物疗效甚微。随着肺纤维化发病机制的进展，多种潜在的抗肺纤维化药物靶点被发现。本文概述肺纤维化的流行病学情况、病因和发病机制，重点介绍作用于炎症、氧化应激、肺泡上皮细胞、肌成纤维细胞等靶点的抗肺纤维化药物的开发现状及展望。

英文摘要：

Pulmonary fibrosis is a serious public problem threatening people＇s health with a median survival time of 2-3 years after diagnosis. Currently, anti-fihrotic drugs have showed little effect. With the advances of mechanisms of pulmonary fibrosis, multiple potential anti-fibrotic targets have been developed. This review summarizes the epidemiology, etiology and pathogenesis of pulmonary fibrosis, and then emphasizes on the prospects of new anti-fibrotic drugs that mainly target inflammation, oxidative stress, alveolar epithelial ceils and myofibroblasts.