中文摘要：

《国家环境与健康行动计划》（2007—2015）文件指出要提高环境与健康风险评估能力。将基于体外模拟实验的人体可给性应用于污染场地健康风险评估，能够一定程度克服以污染物总量为基准进行风险核算的保守性问题。本研究利用相对可利用度修正毒性参数（经口参考剂量、经口致癌斜率），并对其合理性进行了分析，同时推导了筛选值和致癌风险值／危害商的计算公式。建议：（1）建立符合不同土壤类型的人体可给性方法；（2）建立基于关键影响因子的人体可给性预测模型和基于人体可给性的相对可利用度预测模型；（3）优化健康风险评价计算模型。旨在权衡“污染场地再利用”经济效益和人体健康的关系，完善重金属污染场的健康风险评价体系。

英文摘要：

＂National Environment and Health Action Plan＂ （2007--2015） indicated that it was important to improve the ability of environment and health risk assessment. The health risk calculated based on sites bioavailability fraction of heavy metals is more realistic than the one based on the total concentration of heavy metals in soil, which overcomes the conservatism of the risk of accounting issues to a certain extent. In this study, toxicity parameters （the oral reference dose and oral carcinogenic slope） were corrected by the relative bioavailability of heavy metals, which reasonableness was also analyzed. In addition, the formulas of screening value and cancer risk value were deduced. Finally, three aspects were suggested： （1） screening appropriate in vitro methods of different soil types; （2） establishing the relative bioavailability prediction model based on the key impact factor and relative assimilability prediction model based on bioavailability; （3） optimizing the health risk assessment calculation model. This paper aims to weigh the relationship between the economic benefits and human health in the reuse of heavy metal contaminated site, thus completing the health risk assessment system in heavy metal contaminated sites.