中文摘要：

目的探讨利用散斑追踪法检测凝固性坏死发生的可行性。方法利用散斑追踪原理选择相关系数作为评估参数，对比治疗前后靶区声像图的相似程度，并检测凝固性坏死的情况。结果共进行辐射180个点，利用灰度处理软件判断组织发生凝固性坏死的正确率为65．60％，错误率为34．40％。以90W为例，辐照后有凝固性坏死发生且有明显灰度变化时，相关系数绝对值小于0．58，辐照后有凝固性坏死发生且无明显灰度变化时，相关系数绝对值小于0．75。结论散斑追踪法较利用强回声判断凝固性坏死的方法更敏感，且当图像采集条件保持一致时有很高的稳定性，可能会成为检测凝固性坏死的一种新手段。

英文摘要：

Objective To study the feasibility of utilization of speckle tracing principles to detect the incidence of coagulation necrosis caused by high intensity focused ultrasound （HIFU）. Methods In order to detect the incidence of coagulation necrosis, the correlation coefficients were selected as evaluation parameters to compare the similarity of target ultrasound image before and after HIFU radiation with the speckle tracing principles, and histogenesis of coagulation necrosis was detected. Results There were 180 points of radiation, and the correct rate and error rate was 65. 60% and 34.40% respectively with gray processing software to determine histogenesis of coagulation necrosis. Taking the radiation power of 90 W for example, when the correlation coefficients was lower than 0.58, there was both incidence of coagulation necrosis and obvious gray variation; when the correlation coefficients was less than 0.75, there was no gray variation but coagulation necrosis occurred. Conclusion Speckle tracing is more sensitive than strong echoes way in the judgment of the coagulation necrosis, and the stability is very good when the image acquisition conditions keep consistent. Speckle tracing can become a new way to detect the incidence of coagulation necrosis.