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中文摘要：
目的研究重复应激对5-羟色胺（5-HT）耗竭大鼠海马糖皮质激素（GR）、盐皮质激素（MR）受体表达的影响。方法按体重匹配原则将大鼠随机分为应激组、5-HT耗竭组、5-HT耗竭应激组和对照组各12只。采用限制应激模型,5-HT耗竭组采用连续2d对氯苯异丙胺（p-PCA）200mg/kg腹腔注射,非5-HT耗竭组采用生理盐水注射对照;以免疫组化法比较海马各区GR/MR蛋白免疫反应性。结果应激组海马CA1、CA2、CA3、CA4区和齿状回（DG）GR免疫反应性分别高于对照组的CA1（P〈0.05）、CA2（P〈0.05）、CA3（P〈0.01）、CA4（P〈0.01）和DG（P〈0.01）,在5-HT耗竭组与对照组、5-HT耗竭组与5-HT耗竭应激组之间差异无统计学意义（P〉0.05）;海马各区MR灰度值在上述4组间的差异均无统计学意义（P〉0.05）。结论5-HT耗竭大鼠在重复应激中海马GR受体功能受到抑制,可能是5-HT水平低下个体对应激适应能力下降、从而导致应激相关障碍易感性增加的生物学基础。
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