中文摘要：

目的青少年重性抑郁障碍（major depression disorder,MDD）患者存在特定脑区的结构及功能连接异常,但有关异常脑区的双侧半球间功能连接的改变状况还未知。本研究通过计算青少年MDD患者功能磁共振图像（fMRI）信号的全脑对称体素同胚连接性（voxel-mirrored homotopic correlation,VMHC）,对患者大脑双侧功能对称性的改变进行探索。方法对12例首发未用药的青少年MDD患者及12例年龄性别均匹配的正常青少年进行fMRI数据分析,计算全脑VMHC,并与抑郁及焦虑程度评分进行相关分析。结果与正常青少年相比,MDD青少年的VMHC在中央后回、Rolandic岛盖及脑岛表现为显著性降低,未发现这些脑区的VMHC数值与抑郁程度及焦虑程度评分具有相关性。结论研究结果表明感觉及情绪相关脑区VMHC的降低可能在青少年MDD发生发展中起到重要作用。

英文摘要：

Objective： Evidence has suggested that adolescent major depression disorder（MDD） is associated with structural and functional abnormalities in many brain regions most of which are bilateral.However,depression-related functional alterations between the cerebral hemispheres remain unclear.In the present study,the voxel-mirrored homotopic connectivity（VMHC） was utilized to evaluate the inter-hemispheric functional connectivity alterations in adolescent MDD patients.Methods： Functional MRI data of 12 first-episode,drug-naive adolescent patients with MDD and 12 age-,gender-matched healthy subjects were processed.The whole brain VMHC was calculated and correlation analysis was performed between the regional VMHC and psychological scores.Results： Compared with the healthy controls,adolescents with MDD showed lower VMHC in postcentral gyrus,Rolandic operculum and insula.No significant correlation was found between the VMHC of the 3 brain regions and the psychological scores.Conclusion： The results suggest that decreased VMHC in brain regions is related to somatosensory and emotional process may underlie the pathogenesis of adolescent MDD.