中文摘要：

端粒DNA形成的独特二级结构G-四链体对端粒酶的活性有明显抑制作用,能达到促进肿瘤细胞凋亡的作用。研究表明,能够诱使端粒DNA形成G-四链体及可以稳定这种结构的药物均可能成为有效的化疗药物。金属配合物由于其合成路径简单、结构多变、金属中心所携带的正电荷有利于与G-四链体的沟区、loop环以及带负电荷的磷酸骨架作用,增强其稳定性,因此越来越多的过渡金属配合物被设计用来研究与G-四链体作用。该文综述了近年来金属配合物与G-四链体DNA相互作用方面的研究进展。

英文摘要：

The activity of telomerase can be prohibited by the secondary structure of the telomere DNA-G-quadruplex formed by the single chain in G-rich field,resulting in the apoptosis in tumor cells.Compound which can induce the formation or stabilize the structure of G-quadruplex might be potential anticancer drug.The relative ease of synthesis,the variable structure and the positively charged center enable the metal complexes to interact with the grooves and loops of the quadruplex and negatively charged phosphates backbone.Therefore,many metal complexes have been designed and synthesized.This paper reviews the discoveries in the interaction of G-quadruplex with metal complexes in the past years.