中文摘要：

目的：对兔采用自体骨、异体骨及组织工程骨移植进行腰椎后外侧横突间融合手术,比较分析MRI、CT、X线3种影像手段在早期骨移植中的诊断价值。方法：分别在30只健康新西兰大白兔的双侧腰椎横突间植骨并制备模型,依据填充的材料不同随机分为三组。A组：组织工程骨材料;B组：自体移植骨材料;C组：异体移植骨材料。术后2、4、6周行骨密度检测,CT及MRI检测。结果：X线及CT显示术后6周用组织工程骨作为移植材料的骨密度值、横突间融合率明显高于自体骨及异体骨。MR动态增强扫描（DCE-MRI）能早期无创监测移植骨新骨形成的骨基质中原始微血管的形成过程,判断移植骨存活情况。结论：MRI、CT、X线联合应用能监测兔腰椎融合术后的移植骨修复过程。动态增强MRI对早期骨移植是否成功有很好预测作用。

英文摘要：

Purpose：Posterolateral intertransverse process fusion was performed in rabbit lumbar spine using the autogenous iliac,the allogeneic bone and the tissue-engineered bone.Diagnostic value of MRI,CT,radiography was evaluated at the early phase of bone transplantation.Methods：Thirty healthy New Zealand white rabbits with bilateral lumbar intertransverse bone grafting were used as models for comparision in our study.The rabbits were divided into 3 groups according to the materials used for defect filling,A： the tissue-engineered bone graft group,B： the autogenous iliac group,C： the allogeneic bone graft group.Gross inspection with bone density testing,CT and MRI were done at 2 weeks,4weeks,and 6 weeks.Results： Six weeks after surgery,radiography and computed tomography indicated that the bone density and posterolateral fusion rate of tissue-engineered bone graft group was obviously higher than other two groups.DCE-MRI was an noninvasive method,which can early monitor primitive microvascular forming process in bone stroma during allograft new bone formation,and determine the graft survive.Conclusion： Combined with MRI,CT and radiography,the graft healing process of the rabbit lumbar spinal fusion surgery can be monitered.DCE-MRI has a good prediction value on early success of bone transplantation.