中文摘要：

报道了一种由卤键引发的自由基型双异腈插入反应.多氟烷基溴化物作为卤键的给体,有机碱作为卤键的受体.在可见光照射下,卤键复合物发生单电子转移过程生成多氟烷基自由基,被邻二芳基异腈捕获生成2-多氟烷基化喹喔啉衍生物.该反应在室温条件下进行,产率高,底物适用性广.反应的自由基属性可以通过EPR实验验证.2-多氟烷基化喹喔啉衍生物中3-位氢源可以通过氘代实验确定,实验显示氢源来自于有机碱和溶剂,而且溶剂是最主要的氢源.

英文摘要：

A halogen-bond-promoted double radical isocyanide insertion of o-diisocyanoarenes with perfluoroalkyl bromides is reported, in which perfluoroalkyl bromides as halogen bond donors and organic bases as halogen bond acceptors. Fluoroalkyl radicals can be generated by a visible-light-induced single electron transfer（SET） process. Fluoroalkyl radicals are trapped by o-diisocyanoarenes to give 2-fluoroalkylated quinoxaline derivatives. These reactions could be carried out under mild conditions with good chemical yields and broad substrate scope. A broad range of fluoroalkyl bromides with different functionalities could undergo this reaction to give the corresponding quinoxaline derivatives in good yields. A variety of o-diisocyanides could be fluoroalkylated to give quinoxalines under our established conditions. The radical nature of this reaction was confirmed by electron paramagnetic resonance（EPR） experiments using tert-butyl-α-phenylnitrone（PBN） as a spin trap. When PBN was introduced into the reaction mixture, a spectrum signal attributed to the spin adduct C8F17-PBN appeared as a triplet of doublets. Without light and amine, almost no signal was observed. These phenomena strongly suggested that the perfluoroalkyl radical was the key intermediate and the generation of the intermediate heavily relied on the presence of light and amine. A series of deuteration experiments were performed and these results suggested that both the amine and solvent could serve as the hydrogen source and solvent was the major source.