中文摘要：

RNA干扰（RNAi）是由双链RNA（dsRNA）引发的转录后基因沉默（FIGS）。dsRNA经Dicer酶降解成21．23nt的siRNA。并以其为模板，特定位点、特定间隔地降解与之序列相应的mRNA。随着RNAi机制的深入研究与广泛应用，目前该技术已经普遍应用于凋-2研究中，在阐明启动与调控凋亡机制的同时也为基因治疗提供了新靶点。

英文摘要：

RNA interference is a mechanism of post-transcriptional gene silencing （PTGS） induced by doublestranded RNA. dsRNA is firstly degradated into 21-23nt siRNA by Dicer RNase, and then makes itself as a template,trlggers the mRNA that specifical to the model sequence-to degradate at the specific site and the specific spacing. Along with the deep study and the wide application of RNAi ,now this strategy has been applied in apoptot- ie research, it can not only elucidate various mechanisms about priming and regulation of apoptosis, but also supply several new targets for gene therapy.