中文摘要：

肿瘤微环境是肿瘤细胞的复杂生态环境,细胞与环境共同进化,环境为细胞的恶性转化提供支持。在被招募到肿瘤发生位点的细胞中,巨噬细胞的数量最多,在肿瘤发展的各阶段都存在,人们将其称为肿瘤相关巨噬细胞（tumor associated macrophages,TAM）。CSF1（macrophage colony-stimulating factor 1）是目前公认的经典的促肿瘤细胞因子,它可招募巨噬细胞到肿瘤区域,并促进肿瘤细胞与巨噬细胞的相互作用,进而导致微环境中释放各种促肿瘤发展的生长因子,从而促进肿瘤的发生发展。本文主要阐述了CSF1在肿瘤微环境中发挥的功能作用,为针对CSF1/CSF1R信号而发展的肿瘤治疗策略提供更好的理论基础。

英文摘要：

Tumor microenvironment is a complex ecological environment of tumor cells. Cells co-evolve with the environment, and the environment provides support for tumor cells during the transition to malignancy. Among cells be recruited to the tumor sites, macrophages are the most abundant tumor stromal cells, and they exist during all stages of tumor development, thus are named as tumor-associated macrophage （TAM）. CSF 1 [colony stimulating factor 1 （macrophage）] is recognized as a classic cytokine that promotes tumor pro- gression, and it can recruit macrophages to tumor sites and promote the interaction between tumor cells and macrophages. As a result, many kinds of growth factors that promote tumor development are released from the tumor microenvironment. And ultimately these changes of tumor microenvironment promote the tumor development. In this review, we mainly discuss the recent understanding of the functions of CSF1 in tumor microenvironment, and targeting on the CSF1/CSF1R signaling could be a purposeful strategy to revise the tumor microenvironment.