中文摘要：

目的探讨Wistar大鼠生后海马发育过程中钙／钙调蛋白依赖性蛋白激酶Ⅱ（CaMKⅡ）的表达。方法应用免疫荧光方法检测CaMKⅡ在生后不同时期大鼠海马CA1、CA3区和齿状回（DG）中的表达情况（n=48）。结果CaMKⅡ于生后各期海马CA1区和DG的表达逐渐增强，生后第10天（P10）达高峰期，此后逐渐减弱；于CA3区的表达在P4和P10时均较高。其中，CaMKⅡ在CA3区的表达高于在CA1区和DG的表达，在多形层和分子层的表达高于在锥体细胞层或颗粒细胞层的表达。结论CaMKⅡ在CA1、CA3区和DG中的表达具有特异性的时空分布模式，这可能与其在生后发育过程中的突触发生，树突、轴突形成，海马的成熟以及学习记忆功能相关。

英文摘要：

Objective To investigate the expression of calcium/calmodulin-dependent protein kinase Ⅱ （CaMK Ⅱ） in the Wistar rat hippocampus during postnatal development. Methods Immunofluorescent staining was applied to observe the expression of CaMK Ⅱ in the CA1, CA3 and dentate gyrus （DG） of the rat hippocampus during postnatal development （n =48）. Results In CA1 and DG, CaMK Ⅱ expression increased with age, reached a plateau at postnatal day 10 （P10） and then declined gradually. In CA3, CaMK Ⅱ expression reached a plateau at P4 and PIO. The expression of CaMK H in CA3 was higher than that in CA1 and DG. CaMK Ⅱ expression in the stratum polymorphum and stratum moleculare was much higher than that in the stratum pyramidale or granular cell layer. Conclusion The expression of CaMKⅡ has a specific temporal-spatial distribution pattern. The specific temporal-spatial distribution pattern may be important to the different physiological functions of CaMK Ⅱ during postnatal development such as synaptogenesis, axonal and dendritic arborization, the maturity of hippocampus, learning and memory.