中文摘要：

目的：探讨异位Ⅰ号方对子宫内膜异位症（EMs）模型大鼠血液流变学指标、肿瘤坏死因子α（TNF-α）及血管内皮生长因子（VEGF）水平变化的影响。方法：60只雌性大鼠随机取8只为正常对照组,其余以腹腔内子宫内膜自体移植法进行EMs造模,测定EMs大鼠模型经异位Ⅰ号方治疗前后血液流变学指标及TNF-α及VEGF水平。结果：EMs模型组大鼠全血黏度、全血还原黏度以及红细胞聚集指数均高于正常对照组（P〈0.05或P〈0.01）;经异位Ⅰ号方25g·kg-1·d-1治疗4周后,全血黏度、全血还原黏度（中切、高切）较治疗前降低（P〈0.05）。EMs模型组大鼠TNF-α、VEGF水平均高于正常对照组（P〈0.01）;异位Ⅰ号方组治疗后TNF-α水平、VEGF水平均较模型组有显著下降（P〈0.05）。结论：异位Ⅰ号方可以调节EMs大鼠模型病理状态,对调整血液流变学指标及TNF-α、VEGF有较好的效果,是治疗EMs的有效方剂。

英文摘要：

Objective ： To investigate effect of hemorheology, TNF - α and VEGF of endometriosis SD rats model treating by Yi- wei I Prescription. Methods ： Firstly, 60 female SD rats were divided into no-treatment control group （8 SD rats） and experimental group（52 SD rats, by the method of endometrium autologous transplantation）. Secondly, the changes of hemorheology, TNF-α and VEGF before and after were determined by using Yiwei I Prescription. Results：Before treating by Yiwei Ⅰ Prescription, whole blood viscosity,whole blood reduced viscosity,red cell assembling index, TNF-α and VEGF of experimental group were higher than those of control group （P 〈 0. 05 or P 〈 0. O1 ）. After treating for four weeks, whole blood viscosity, whole blood reduced vis-cosity, TNF-α and VEGF were reduced（P 〈 0. 05 ）. Conclusion：Yiwei I Prescription can effectively adjust the pathology condi-tion of EMs SD rat model by reducing the higher hemorheology,TNF-α and VEGF.