中文摘要：

目的：通过模体实验验证本文所提时域乳腺扩散光层析成像（DOT）方法的有效性和可行性.方法：利用搭建的多通道时间相关单光子计数技术（TCSPC）的多通道DOT测量系统对圆柱形模体进行实验数据测量,并将测量数据代入本文所提时域扩散光层析成像算法中进行吸收和散射系数图像重建.结果：重建所得吸收和散射系数图像中肿瘤位置与实际相符,但尺寸略大于实际情况.两者的重建值分别达到实际值的50％和30％左右.结论：通过应用自主搭建的TCSPC的DOT测量系统和本文所提算法进行二维实验验证,结果显示可以较好地重建出乳腺肿瘤位置、大小和光学参数值,为进一步的乳腺DOT临床实验打下基础.

英文摘要：

Purpose：This study aimed to verifiy the viability and effectiveness of time-domain diffuse optical tomography （DOT） method used in this article by phantom experiment.Methods：The methodology was based on a specifically designed multi-channel time-correlated single photon counting （TCSPC） DOT system as well as image reconstruction scheme that employed the diffusion equation as the forward model.We had validated the methodology using cylindrical-shaped phantom experiment,and we obtained the images of absorption and scattering coefficients.Results：The reconstructed image showed that the DOT method was able to reasonably disclose the target location,but the recovered target size was larger than actual situation.For the quantitative ratio,both recovered values were below the actual value.Conclusion：We tested the proposed approach in two-dimensional experiment.The result showed that the proposed methodology,combining with the specifically-designed multi-channel TCSPC system,can successfully recover the target size,location and optical values.Clinical evaluations of the proposed methodology are going on and the results will be reported in successive papers.