中文摘要：

目的以补阳还五汤为模型药方,探索有效成分群（部位）溶度参数的变化规律。方法用均匀设计、星点设计安排实验方案,用改良反相气相色谱法（IGC）测定溶度参数值,用SPSS软件拟合曲线方程。结果得出有效成分黄芪甲苷（X1）、阿魏酸（X2）、芍药苷（X3）、川芎嗪（X4）的溶度参数的递推方程为Y=-69.016＋435.277 X1X2＋336.966 X2X4＋487.702X3X4-54.575 X12-59.696 X2X3（r=1.000,P〈0.01）;有效部位总苷类（X1）、总生物碱（X2）、总多糖（X3）的溶度参数的递推方程为Y=21.822＋10.562 X1＋51.512 X2-37.078 X3＋163.820 X1X2-155.569 X1X3-506.750 X2X3-9.385 X12＋19.864 X22＋413.446 X32（r=0.866,P〈0.01）。结论建立的递推规律方程揭露了中药单一成分与复杂体系间的必然联系及递推规律,为中药复方溶出规律研究奠定了基础。

英文摘要：

Objective To take Buyanghuanwu Decoction as a model for exploring the variable rule of solubility parameters for the effective components group （fraction）. Methods To arrange the experiment design by uniform design and central composite plan, to determine the solubility parameter values with the modified inverse gas chromatography （IGC）, and to fit the curve equation using SPSS ＇software. Results The recursive equation for the major active component including astragaloside （Xl）, ferulic acid （X2）, paeoniflorin （X3）, and lignstrazine （X4） was Y = -69.016 ＋ 435.277 XIX2 ＋ 336.966 X2X4 ＋ 487.702 X3X4- 54.575 Xl2- 59.696 X2X3 （r = 1.000, P 〈 0.01）; The recursive equation for the active part including total glycosides （X1）, and total alkaloids （X2）, total polysaccharide （X3） was Y = 21.822 ＋ 10.562 Xl ＋ 51.5 i2 X2--37.078 X3 ＋ 163.820 X1X2--155.569 XIX3--506.750 X2X3--9.385 X12 ＋ 19.864X22 ＋ 413.446 X32 （r = 0.866, P 〈 0.01）. Conclusion The recursive rule equation has revealed the inevitable connection between the single component of Chinese materia medica and complex system, which could lay the foundation for the further research on the solubility rule of traditional Chinese medicine compound.