中文摘要：

将实验动物分为光热治疗组、光动力治疗组、光热和光动力协同治疗组，使用T2加权和扩散加权两种磁共振成像方式对治疗效果进行实时监测，并使用病理学方法对磁共振检测效果进行验证。实验结果发现，两个单纯治疗组中肿瘤并未被完全杀灭；而协同治疗组中，肿瘤被完全杀灭。磁共振作为无创监测手段，在疗效评价中有巨大的应用价值，并可对纳米粒子的设计合成起到指导作用。

英文摘要：

This paper assess the long -term curative effect of tumor after different treatment strategies . Compared with photodynamic therapy or photothermal therapy alone , the combined therapy showed a significantly synergistic effect , which was demonstrated by functional MRI .The results provide a di-rect, non-invasive method for in vivo monitoring of the treatment response to nanoparticle -mediated PTT, which can be used to guide cancer therapy to improve potential clinical outcomes .