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Carbon Ion Irradiation Induces Reduction of β-tubulin in Sperm of Pubertal Mice
  • 期刊名称：《中国科学院近代物理研究所和兰州重离子研究装置年报：英文版》
  • 时间：0
  • 分类：Q959.117[生物学—动物学] O734[理学—晶体学]
  • 作者机构：[1]Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou730000, Gansu, China, [2]Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000, Gansu, China, [3]Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000,Gansu, China, [4]University of Chinese Academy of Sciences, Beijing 100049, China, [5]College of Veterinary Medicine,Gansu Agricultural University, Lanzhou 730070, Gansu, China, [6]Department of radiotherapy, Gansu Provincial Hospital,Lanzhou 730000, Gansu, China
  • 相关基金：This research was supported by grants from the National Basic Research Program of China （2010CB834202）, The National Natural Science Foundation of China （10835011）, the Scientific Technology Research Projects of Gansu Province （0702NKDA045, 0806RJYA020）.
作者： LI Hong Yan[1,2,3,4], HE Yu Xuan[5], ZHANG Hong[1,2,3], LIU Yuan Yuan[1,2,3], MIAO Guo Ying[1,6], ZHAO Qiu Yue[1,2,3,4]
关键词： 微管蛋白, 辐照诱导, 精子, 青春期, 碳离子, 小鼠, 微管相关蛋白, 细胞功能
中文摘要：

<正>Microtubules are involved in a variety of cellular functions such as cell division,intracellular transport,maintenance of cell polarity and flagella and ciliary motility.The heterogeneity of tubulin and microtubule-associated proteins is responsible for these different microtubule functions.Many studies have confirmed that the structure and function of the differentα-tubulin andβ-tubulin subunits can affect the microtubule.The sperm axoneme

英文摘要：

Microtubules are involved in a variety of cellular functions such as cell division, intracellular transport, maintenance of cell polarity and flagella and ciliary motility. The heterogeneity of tubulin and microtubule-associated proteins is responsible for these different microtubule functions. Many studies have confirmed that the structure and function of the different α-tubulin and β-tubulin subunits can affect the microtubule. The sperm axoneme microtubule has linear fiber filaments which are polymerized by heterodimeric a and β-tubulin, each with a molecular mass of approximately 50 kD[1].

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