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哮喘模型大鼠气管的张开角及残余应变
  • ISSN号:0258-8021
  • 期刊名称:《中国生物医学工程学报》
  • 时间:0
  • 分类:R318[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]上海中医药大学,上海201203, [2]复旦大学生物力学实验室,上海200433
  • 相关基金:国家自然科学基金资助项目(19972042).
中文摘要:

对哮喘模型大鼠气管的无载荷状态和零应力状态进行分析。与正常组相比,模型大鼠气管软骨剪开的张开角及所对应的残余应变绝对值均较正常组显著增大(P〈0.05),而且随着x/L的增大而呈明显上升趋势。模型大鼠气管肌肉剪开的张开角及所对应的残余应变绝对值无显著变化,且沿气管轴向变化不明显。结果表明哮喘大鼠气管为了适应外在应力环境的变化,肌肉部分不断进行代偿性生长,导致哮喘大鼠气道重建。

英文摘要:

In this study,the no-load state and zero-stress state of the asthma rat trachea were anlayazed. It was found that the opening angle and residual strains of the asthma rat trachea cut at the cartilaginous region was significantly larger than those of the normal rat. Compared with the coutrol rat, it was indicated that the opening angles and residual strains expressed by cutting at the muscular portion were basically identical along longitudinal location and those expressed by cutting at the cartilaginous region increased in the longitudinal direction in the asthma rta. The results shows that the muscle of trachea gradually growed because of changes of the mechanical environment, resulting in remodeling of the asthma rat trachea.

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期刊信息
  • 《中国生物医学工程学报》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国生物医学工程学会
  • 主编:刘德培
  • 地址:北京东单三条9号
  • 邮编:100730
  • 邮箱:cjbmecjbme@163.com
  • 电话:010-65248786
  • 国际标准刊号:ISSN:0258-8021
  • 国内统一刊号:ISSN:11-2057/R
  • 邮发代号:82-73
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:8917