中文摘要：

目的探讨腹腔镜结直肠癌术后应用羟乙基淀粉（130／0．4，6％）对于患者术后恢复的影响。方法选自中山大学孙逸仙纪念医院胃肠外科2011年1月至2011年7月腹腔镜结直肠癌切除术共45例，随机分为羟乙基淀粉组（23例）和血清白蛋白组（22例）。术后3天分别连续使用羟乙基淀粉（130／0.4,6％）500ml／d和人血白蛋白10g／d。比较两组术前及术后1d、3d、5d患者心率（P）、中心静脉压（CVP）、平均动脉压（MAP）、凝血功能（PT、AVTT）、红细胞压积（HCT）、肌酐（Cr）、血清白蛋白以及术后排气时间和术后住院天数。结果两组患者术前临床资料、肿瘤分期、病理分型具有可比性（P〉0．05）。与术前和血清白蛋白组相比，羟乙基淀粉组CVP在术后1d、3d显著升高，差异有统计学意义（P〈0．05）；羟乙基淀粉组HCT在术后1d、3d、5d与术前及血清白蛋白组比较降低，差异有统计学意义（P〈0．05）。而两组在凝血功能（AFIT、PT）、MAP、HR、Cr、白蛋白水平、术后住院时间、及排气时间方面比较，差异无统计学意义（P〉0．05）。结论腹腔镜结直肠癌手术患者围术期应用羟乙基淀粉（130／0．4，6％）可以维持血流动力学稳定、提高血浆胶体渗透压、早期应用可以有效节约白蛋白的使用。

英文摘要：

Objective To investigate the impacts of hydroxyethyl starch（130/ 0.4,6%） （HS） therapy for patients after laparoscopic surgery for colorectal carcinoma. Methods Prom January 2011 to July 2011 ,45 patients of colorectal carcinoma after laparoscopic surgery were enrolled in this study. 23 postoperative patients in the HS group received hydroxyethyl starch （130/0.4,6%） daily for the first three postoperative days; the other 22 postoperative patients in the albumin （ALB） group were given intravenous albumin therapy.Preoperative and postoperative heart rate, mean arterial pressure, CVP, PT, AP3~T, HCT, creatinine, albumin, postoperative length of stay, and postoperative anus exhaust time were compared. Results Preoperative clinical data, tumor stage, and pathological type of the two groups were comparable. There were no significant differences in heart rate, mean arterial pressure, PT, APT]＇, creatinine, albumin, postoperative length of stay, and postoperative anus exhaust time between the two groups （P〉0.05）. Compared with the ALB group and preoperation HS group, the CVP levels on the day 1, and day 3 after surgery were significantly higher in HS group （P〈0.05）; and the HCT levels on day 1, day 3 and day 5 after surgery were significantly lower in the HS group （P〈0.05）. Conclusion Hydroxyethyl starch （130/ 0.4, 6% ） treatment in the early period after laparoscopic resection for colorectal carcinoma can effectively maintain hemodynamics stationary, improve colloid osmotic pressure of blood, and save the use of albumin.