位置:成果数据库 > 期刊 > 期刊详情页
Analysis of pulsatile flow in the parallel-plate flow chamber with spatial shear stress gradient
  • ISSN号:1001-6058
  • 期刊名称:Journal of Hydrodynamics
  • 时间:0
  • 页码:113-120
  • 语言:英文
  • 分类:R318.01[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]Department of Engineering Mechanics, Shanghai Jiaotong University, Shanghai 200240, China, [2]Institute of Biomechanics, Fudan University, Shanghai 200433, China
  • 相关基金:Project supported by the National Natural Science Foundation of China (Grant Nos. 10472027, 30670511)
  • 相关项目:用Hilbert-Huang变换和蛋白质组学技术研究非平稳脉动应力与血管重建
作者: 覃开蓉|
中文摘要:

平行板的流动房间(PPFC ) ,哪个高度是远 smallerthan 它的自己的长度和宽度,为有教养的脉管的 Endothelical 房间(EC ) 的 mechanicalbehavior 的 in-vitro 学习的主要仪器之一暴露于液体砍应力。在 PPFC 的不同类型的 steadyflow 广泛地被调查了,而,脉动的流动 inthe PPFC 几乎没收到很少注意。在几何 sizeand 的特征的考虑在 PPFC 的脉动的流动, 3-D 脉动的流动被分解成 2-D 脉动的流动 inthe 垂直飞机,和一个不可压缩的飞机潜力流动在水平飞机。simplemethod 然后被建议在 PPFC 分析脉动的流动与空间砍 stressgradient。根据方法,脉动的液体砍在几的压力报导了 PPFCswith 空间砍压力坡度被计算。结果是理论上有意义的 forapplying PPFC in-vitro,砍模仿脉动的液体压力环境,到 whichcultured, EC 暴露于。

英文摘要:

The Parallel-Plate Flow Chamber (PPFC), of which the height is far smaller than its own length and width, is one of the main apparatus for the in-vitro study of the mechanical behavior of cultured vascular Endothelical Cells (ECs) exposed to fluid shear stress. The steady flow in different kinds of PPFC has been extensively investigated, whereas, the pulsatile flow in the PPFC has received little attention. In consideration of the characteristics of geometrical size and pulsatile flow in the PPFC, the 3-D pulsatile flow was decomposed into a 2-D pulsatile flow in the vertical plane, and an incompressible plane potential flow in the horizontal plane. A simple method was then proposed to analyze the pulsatile flow in the PPFC with spatial shear stress gradient. On the basis of the method, the pulsatile fluid shear stresses in several reported PPFCs with spatial shear stress gradients were calculated. The results were theoretically meaningful for applying the PPFCs in-vitro, to simulate the pulsatile fluid shear stress environment, to which cultured ECs were exposed.

同期刊论文项目
同项目期刊论文
期刊信息
  • 《水动力学研究与进展:英文版》
  • 中国科技核心期刊
  • 主管单位:中国船舶重工集团公司
  • 主办单位:中国船舶科学研究中心
  • 主编:矣有生
  • 地址:上海高雄路185号
  • 邮编:200011
  • 邮箱:jhdzhou@aliyun.com
  • 电话:021-63150072
  • 国际标准刊号:ISSN:1001-6058
  • 国内统一刊号:ISSN:31-1563/T
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:427